Clean teeth and arthritis

Clean teeth and arthritis

http://www.dailymail.co.uk/health/article-2566343/Clean-teeth-hold-arthritis-Scientists-discover-link-gum-disease-bacteria-early-onset-condition.html

Clean teeth can hold off arthritis: Scientists discover link between gum disease bacteria and early onset of the condition

• Link between gum disease bacterium and onset of rheumatoid arthritis
• Bacterium produces enzyme which reacts with residue of certain proteins
• Body recognises these proteins as intruders, leading to an immune attack

By DAILY MAIL REPORTER

PUBLISHED: 20:32 EST, 23 February 2014 | UPDATED: 20:32 EST, 23 February 2014

 
 
 

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Brushing your teeth well could help prevent arthritis, scientists claim.

Researchers found a link between the bacterium responsible for gum disease and earlier onset of rheumatoid arthritis, as well as faster progression and greater severity of the condition.

The bacterium produces an enzyme which reacts with the residue of certain proteins.

The body recognises these proteins as intruders, leading to an immune attack, the researchers from the University of Louisville’s School of Dentistry in Kentucky said.

Brushing your teeth well could help prevent arthritis, scientists claim. Researchers found a link between the bacterium responsible for gum disease and earlier onset of rheumatoid arthritis

In arthritis patients, the subsequent result is chronic inflammation responsible for bone and cartilage destruction within the joints.

Previous studies have indicated that gum disease is at least two times  more prevalent in rheumatoid arthritis patients.

The bacterium, Porphyromonas gingivalis, produces a unique enzyme, peptidylarginine deiminanse (PAD).

 

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They discovered that PAD changes residues of certain proteins into citrulline, and the body recognises these proteins as intruders, leading to an immune attack. 

In rheumatoid arthritis patients, the subsequent result is chronic inflammation responsible for bone and cartilage destruction within the joints.

Researcher Dr Jan Potempa from the University of Louisville School of Dentistry Oral Health and Systemic Diseases said: 'Taken together, our results suggest that bacterial PAD may constitute the mechanistic link between P. gingivalis periodontal infection and rheumatoid arthritis, but this ground-breaking conclusion will need to be verified with further research.'

In arthritis patients, the subsequent result is chronic inflammation responsible for bone and cartilage destruction within the joints

Dr Potempa and his team studied another oral bacterium, Prevotella intermedia for the same affect, but learned it did not produce PAD or the subsequent effects.

Writing in the study, published in PLOS Pathogens, Dr Potempa said he is hopeful these findings will shed new light on the treatment and prevention of rheumatoid arthritis.

Studies indicate that compared to the general population, people with periodontal disease have an increased prevalence of rheumatoid arthritis and periodontal disease is at least two times more prevalent in rheumatoid arthritis patients. 

Other research has shown that a P. gingivalis infection in the mouth will precede rheumatoid arthritis and the bacterium is the likely culprit for onset and continuation of the autoimmune inflammatory responses that occur in the disease.

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Dr Rader speaks about the affects of diabetes on the oral environment on the radio

http://m.youtube.com/watch?v=HmISGiTLQiU

The host Connie Clark of the radio program A Senior Moment, a local station 89.9 out of Post Falls, Idaho. She posted our interview on you tube about the affects of diabetes in the oral environment. There are a couple pauses for commercial breaks that don't have audio but it keeps playing.

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Oral bacterial community makes a difference

Intereseting info about different oral community of bacteria based on hunter/gatherer diet.

http://www.npr.org/blogs/health/2013/02/24/172688806/ancient-chompers-were-healthier-than-ours

Ancient Chompers Were Healthier Than Ours
by AUDREY CARLSEN
February 24, 2013 5:05 AM

Prehistoric humans didn't have toothbrushes. They didn't have floss or toothpaste, and they certainly didn't have Listerine. Yet somehow, their mouths were a lot healthier than ours are today.

"Hunter-gatherers had really good teeth," says Alan Cooper, director of the Australian Centre for Ancient DNA. "[But] as soon as you get to farming populations, you see this massive change. Huge amounts of gum disease. And cavities start cropping up."

And thousands of years later, we're still waging, and often losing, our war against oral disease.

Our changing diets are largely to blame.

In a study published in the latest Nature Genetics, Cooper and his research team looked at calcified plaque on ancient teeth from 34 prehistoric human skeletons. What they found was that as our diets changed over time — shifting from meat, vegetables and nuts to carbohydrates and sugar — so too did the composition of bacteria in our mouths.

Not all oral bacteria are bad. In fact, many of these microbes help us by protecting against more dangerous pathogens.

However, the researchers found that as prehistoric humans transitioned from hunting and gathering to farming, certain types of disease-causing bacteria that were particularly efficient at using carbohydrates started to win out over other types of "friendly" bacteria in human mouths. The addition of processed flour and sugar during the Industrial Revolution only made matters worse.

"What you've really created is an ecosystem which is very low in diversity and full of opportunistic pathogens that have jumped in to utilize the resources which are now free," Cooper says.

And that's a problem, because the dominance of harmful bacteria means that our mouths are basically in a constant state of disease.

"You're walking around with a permanent immune response, which is not a good thing," says Cooper. "It causes problems all over the place."

In addition to oral disease, those problems may include diabetes, obesity and even heart disease.

According to Cooper, bacteria make up approximately 90 percent of the cells in our bodies. He believes that we focus too much on ourselves and not enough on this so-called microbiome.

"We brush our teeth and we floss, and we think that we've got good oral hygiene. But [we're] completely failing to deal with the underlying problem," he says. "Ten years from now, I think we're going to find that the whole microbiome is a key part of what you get monitored for and treated for."

As for right now, Cooper suggests that one way to help return your microbiome to a healthier, more balanced state might be to cut out all of those processed carbs and start eating like our ancestors.

Sounds like he's another fan of the paleo diet.

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